These evidence-based interventions remain the most effective approach to improving liver health and preventing disease progression
Multiple mechanisms including loss-of-function mutations in the genes encoding NRF2 or small Mafs, oxidation or epigenetic modification of the NRF2 promoter, or changes in the other factors that modulate NRF2 (such as kinases, phosphatases, or DNA binding proteins) have been suggested to contribute to the suppression of NRF2 activity during ageing
Proshkina E, Plyusnin S, Babak T, Lashmanova E, Maganova F, Koval L, et al
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doi:10.7326/0003-4819-158-9-201305070-00003
Lien, F