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Most GLP-1 medications including Ozempic (semaglutide), Wegovy, Mounjaro (tirzepatide), and Zepbound can be taken with: oral antihistamines (cetirizine, loratadine, fexofenadine) nasal steroid sprays (fluticasone, mometasone) asthma inhalers leukotriene modifiers (montelukast) allergy drops (SLIT) allergy shots decongestants (with some caution) Current AAAAI and NIH guidance show no known harmful interactions between these drug classes