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It is also well known that high reactivity, longer circulation time, off-target nanomaterial accumulation, and unintentional exposure are the main risks of NP toxicity (Johnston et al., 2010

International Union of Basic and Clinical Pharmacology

In a phase 2 study in people with obesity (without T2D), retatrutide (doses 1 to 12 mg) has led to a dose-dependent WL up to 24.2% at the end of the 48-week treatment period compared to 2.1% with placebo [81]

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