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Graphical abstract Similar content being viewed by others 1 Introduction to ROS Despite of significant progress in medical sciences, there are always challenges to mitigate the oxidative stress-mediated diseases via cellular and biological damages

Int J Mol Med

ACS Chem Neurosic 10 (2), 777782

Aging reduces NAD+ synthesis pathways while increasing consumption by enzymes like CD38 and PARPs, activated by inflammation and damage.[13][15] CD38, an immune-related enzyme, ramps up with age, breaking down NAD+ precursors

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