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As shown, liver preservation with IGL-1+MEL+TMZ caused a significant decrease in endoplasmic reticulum (ER) stress - a decrease in GRP78, PERK, and CHOP, activation of AMPK which in turn led to a decrease in ER stress and autophagy

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The western blot revealed the presence of covalently linked high molecular weight TrxR1 oligomers following oxidation with H 2 O 2 (Supplementary Figures S2, S3)

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PMID: 83 ScapiniPCassatellaMA