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In the intrinsic pathway, oxidative stress or GSH depletion induces BAX SSG at Cys62, promoting its mitochondrial translocation and subsequent activation of CASP9 and CASP3 44

Interestingly, each of these processes can be inhibited by iron chelators [214]

10.1182/blood-2020-137266 170 ScaliseM.PappacodaG.MazzaT.ConsoleL.PochiniL.IndiveriC