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These benefits continue to grow as the medication becomes more effective and as patients become empowered to take control of their health and maintain long-term weight loss

However, limitations involve unknown user demographics, reliance on self-reported data, and the inability to confirm medication duration or dosage

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A meta-analysis of seven SURPASS clinical trials in participants with T2DM showed the hazard ratios comparing tirzepatide versus controls of 0.80 (95% CI, 0.57 1.11) for 4-MACE, 0.90 (95% CI, 0.50 1.61) for cardiovascular death, and 0.80 (95% CI, 0.51 1.25) for all-cause mortality (264)

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