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On top of all this is the most dangerous effect: damage to the cardiovascular system

As of February 2026, Lilly plans to submit for orforglipron for type 2 diabetes sometime in 2026

Tirzepatide is also not advised for individuals with a history of pancreatitis or current pancreatic disorders, as well as for pregnant or breastfeeding women, as safety data is insufficient for these conditions

We provide individualized treatment plans, ongoing medical supervision, and practical coaching that supports lasting lifestyle changes

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Until more data is available, use in patients with recent heart attacks or severe heart failure should be approached cautiously under medical supervision