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In addition to the US FDA approved GLP-1RAs, there are GLP1/glucagon dual agonists (Cotadutide, BI 456906), GIP/GLP1 dual agonists (Tirzepatide, GIP/GLP peptide I and II), GIP/GLP1/glucagon tri-agonists (HM15211, GGG tri-agonist) and GLP1R agonists (Efpeglenatide, Rybelsus) currently in phase 1- III clinical trials for T2D, obesity, and NASH (MASH) treatments (12)

One notable finding is that all participants on mazdutide experienced increased heart rates

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The volume bet baked into Novos guidance is that cutting effective monthly out-of-pocket costs from roughly $1,000 to the $245 to $350 range for Medicare, Medicaid, and TrumpRx buyers could unlock more than a proportional spike in filled prescriptions

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