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If the body does not get enough B12, there can be serious consequences

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That's a reason to keep on top of your nutrition and strength-training while on these drugs, he writes, "especially for older people like me, who are [already] susceptible to muscle loss." There are people who should steer clear of GLP-1 drugs, Kessler notes, including those with a personal or familial history of certain thyroid and endocrine cancers, those with chronic kidney disease, pancreatitis, inflammatory bowel diseases, uncontrolled diarrhea or constipation or gastroparesis, or if you are pregnant

In people with diabetes, high blood sugar levels increase glucose levels in saliva

When you combine a stable maintenance dose with these behavioral tools, you build the foundation for weight loss that lasts

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