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Among 2-OGDDs, Jumonji C domain-containing histone demethylases and ten-eleven translocation (TET) family DNA demethylases are major enzymes that induce epigenetic modifications using glutamine-derived -KG

It is thought that low level of serum LC in patients with hypertension may be associated with a higher urinary excretion of LC, which may be caused by renal injury in the course of HT

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