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Data from 76 RCTs with 103,371 patients were included in the meta-analysis

Visceral fat tends to respond well to this class of medication, often more so than subcutaneous fat

The induction of targets, such as GCL, requires the activation of upstream transcriptional co-activators

The 26% MACE reduction in SUSTAIN-6, the 20% reduction in SELECT, and the 42% reduction in atrial fibrillation risk from meta-analysis data paint a picture of a medication that protects the heart far more than it burdens it

Since HNMT (the intracellular histamine-degrading enzyme) requires SAMe, impaired methylation can slow histamine clearance, especially in tissues like the brain and airways, where HNMT is the primary clearance pathway