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Recently, retatrutide (also known as LY3437943) 6,7,8,9 has shown impressive efficacy in obesity treatment through triple agonism at GLP-1R, GIPR and GCGR

It has been pointed out that the interaction between RIPK2 and XIAP is a key target for regulating NOD1/2-dependent immune responses, and the potential for drug development targeting this proteinprotein interaction is substantial [374]

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Additionally, there are important concerns regarding long-term safety

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