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For this final rule with comment period, the OPPS payment rates are based on claims submitted between January 1, 2024, and December 31, 2024, processed through June 30, 2025

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Accordingly, we also investigated direct prediction of intrinsic solubility using the provided intrinsic-solubility models: we were surprised to find that the performance of these models was markedly worse, with typical values between 0.3 and 0.5

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