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84(5): 6349 Segre G, Bianchi E, Corsi M, et al

142,143 Research indicates that GLP-1 RAs could play a role in reducing oxidative stress and inflammation, two major factors that contribute to cellular senescence

Table 1: Drugs affecting liver and digestive metabolism can disrupt transmethylation and transsulfuration, raising GGT activity

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Promotes collagen production: Helps strengthen connective tissues such as tendons, cartilage, and skin

In contrast, -LA improved hyperinsulinemia and the higher levels of free fatty acids of the T2DM rats [129], increases antioxidant defense through Nrf2, and reduces inflammation in T2DM (decreases TNF- and Inhibit the expression of NLRP3 and downstream inflammatory factors IL-18 and IL-1) to prevent liver steatosis and relieve HFD-induced liver lipid accumulation in T2DM rats (Table 7)