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Milk thistle can be used to support phase 1 and phase 2 detoxification pathways through its antioxidant, cell membrane stabilisation, protein synthesis and bile production actions The phase 1 pathway attempts to break down compounds for excretion via oxidation, hydrolysis or reduction reactions facilitated by the cytochrome P450 enzyme system

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Diabetes 50 , 227232 (2001)

The differential equations corresponding to the reactions diagramed in Figure1 are listed below

That said, a significant die-off reaction can also be a signal that detoxification pathways need more supportmore on this below

Taleb SA, Ibrahim BMM, Mohammed MA, Yassen NN, Hessin AF, Gad SA, et al