However, to explore the possibility that these peptides might modulate glucose homeostasis via their effects on circulating levels of glucagon, glucagon secretion from islets treated with GEP44 or GEP12 was measured, both in the presence and the absence of Y1-R antagonists (Fig
doi: 10.5966/sctm.2012-0058 87 ShahSMansourHMAguilarTMLucke-WoldB
We will also summarize how these physicochemical factors affect the peptide drugs application in disease treatment and evaluate the efficacy of chemical modification strategies in therapeutic applications, with the aim of providing references and guidance for the design and optimization of therapeutic peptides
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