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Severe calorie restriction in perimenopause can actually make things worse by: Further decreasing metabolic rate (adaptive thermogenesis) Increasing cortisol (chronic stress response) Promoting muscle loss over fat loss Disrupting already-irregular hormone patterns Ive seen women eating 1200 calories and doing intense cardio six days per week, completely exhausted and still gaining weight

secondary amines are thought to be better tolerated than tertiary amines [55]

After your body uses estrogen, it must transform it into less active forms and safely excrete it through conjugation

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doi: 10.1159/000514273 161 GoradiaE

Hormonal Regulation Insulin helps lower homocysteine (Hcy) by turning it into methionine, which reduces cysteine and glutathione (GSH) production