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Limited long-term data: most evidence is from animal models, with no long-term human study of NNMT inhibition and oncological endpoints

It participates in the conversion of homocysteine to methionine and the metabolism of methylmalonic acid, both crucial for energy production at the cellular level

It suggests a profound impact on appetite regulation, satiety, and potentially even mood and reward pathways

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However, Medicare Part D is unlikely to cover B12 shots or other supplements