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This clinical reality has prompted interest in adjunctive therapies that might address both thyroid-related and metabolic aspects of the condition, though such approaches require careful evaluation and medical supervision

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[PowerPoint Presentation] [6] United States Food and Drug Administration

If you have a history of heart failure or bladder cancer, pioglitazone is generally avoided

Non-oral contraception or backup contraception is recommended for 4 weeks after initiation and after each dose increase

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