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Alternative Routes of Administration & the First-Pass Effect There are several reasons for different routes of administration used in clinical medicine ( Table 33 )for convenience (eg, oral), to maximize concentration at the site of action and minimize it elsewhere (eg, topical), to prolong the duration of drug absorption (eg, transdermal), or to avoid the first-pass effect (sublingual or rectal)
The heart, in particular, depends on a continuous and substantial supply of ATP to maintain its function, which is why CoQ10 has been one of the most studied supplements in the context of cardiovascular support.*
A 99% COA proves the vial is safe. Chromatographic purity may support one aspect of chemical assessment
Arch Fam Med 3(2):193-5
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By facilitating the elimination of these harmful substances
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