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The proautophagosome gradually develops into a vacuole with a double membrane structure, which is surrounded by degraded organelles and some cytoplasm ( According to the different ways of transporting substrates to lysosomes, autophagy can be divided into three main ways: macroautophagy, microautophagy, and chaperone-mediated autophagy (CMA) ( In addition, autophagy can be classified into selective autophagy, aggregative autophagy, and xenophagy, etc

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