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5-Amino-1MQ is a small molecule that inhibits nicotinamide N-methyltransferase (NNMT), an enzyme involved in methylation and NAD+ metabolism

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The most common side effects reported are minor temporary injection site redness or mild headache in some individuals

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Depletion of puf-8 results in derepression of PAL-1 in germline SPCs and PAL-1-dependent misexpression of HLH-1 in germ cells (Mainpal et al., 2011)