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JAMA Neurol

The formation of ROS is also a consequence of defective mitochondria that, additionally, leads to the activation of the inflammasome and of the pro-inflammatory nuclear factor kappa-light-chain-enhancer of activated B cells (NF-B)

- Nn s dng 2 ln/ngy (sng v ti)

and modLates functional chemistry and dysregulated metabolic pathways

This is more physiologically appropriate and likely explains why the combination of PTD-DBM (upstream release) with valproic acid (downstream activation) produces synergistic rather than merely additive effects

Can be combined with microneedling (dermarolling) to enhance penetration depth and follicle reach