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Inhibition of bcl-2 with liposomal p-ethoxy antisense oligonucleotides induces apoptosis in the presence of high level of bcl-xl and is critically depending on baseline bcl-2 levels in AML

Cells were exposed for 48 h, the cleared cell extracts were incubated with DEVD-p-nitroanilide and caspase-3 activity was measured spectrophotometrically

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Studies show that IGF-1 levels may affect body fat reduction and metabolism, IGF-1 is linked to body fat and body mass index