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While dietary and lifestyle factors influence IGF-I levels, IGFBP-3 appears to be less sensitive to variations in dietary macronutrients

These changes have important aesthetic implications, including soft tissue ptosis due to a mismatch between skin envelope and underlying volume, particularly evident as sagging along the jawline

J Neuroimmune Pharmacol 16 , 7489 (2021)

doi: 10.1001/jamanetworkopen.2025.26013, 2

This can make it harder to stick to a healthy eating plan or stay active, which are both important for long-term weight loss

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