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[2] [3] [11] Tissue deficiencies may negatively affect nerve cells, bone marrow, and the skin

Jain and Katti, 2015

Glutathione may potentially interact with certain medications, particularly chemotherapy agents where glutathione's protective effects might theoretically affect treatment efficacy, nitroglycerin and other nitrates used for cardiovascular conditions, and immunosuppressive medications where glutathione's immune-supportive effects might theoretically reduce medication effectiveness

Alternative sweeteners such as xylitol and mannitol with stevia are OK in small amounts

While not every user becomes deficient, the risk is substantial enough to warrant proactive supplementation, particularly during aggressive weight loss phases

Its studied as a selective NNMT inhibitor in laboratory settings