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Can you talk about what those were and what you learned

Sitagliptin An approximately 2-fold increase in the plasma AUC of sitagliptin was observed in patients with moderate renal insufficiency, and an approximately 4-fold increase was observed in patients with severe renal insufficiency including patients with ESRD on hemodialysis, as compared to normal healthy control subjects

Some participants withdrew from the 12 mg arm because they could not tolerate the escalation, whereas most completed the 4 mg and 8 mg dose levels

Use a piece of tape or a date opened sticker on the vial

Burke OM, et al

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