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Owing to the velocity of blood movement through the voxel, MRS does not detect GSH signal from blood, thus, the measured GSH values reflect only GSH in brain parenchyma or CSF

Moreover, treatment with AST mitigated cytotoxicity, dysfunction of mitochondria, and oxidative stress induced by rotenone in a dose-dependent manner in SK-N-SH cells

For instance, mitochondrial augmentation therapy (MAT) for children with single large - scale mitochondrial DNA deletion syndromes (SLSMDs) showed no serious side effects, no immune rejection, normal blood/metabolism, and higher mtDNAbut this is preliminary (205)

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Additionally, ensuring adequate intake of essential cofactors like selenium (required for Glutathione Peroxidase activity) and B-vitamins (required for the glutathione reductase recycling process) can help optimize the body's ability to utilize the supplemented glutathione