These data suggest hair loss on tirzepatide and hair loss on semaglutide can occur for some patients during active weight reduction, but it is not universal and was generally mild in studies
Important additional warnings include: discontinuation if pregnancy is recognized
It usually improves significantly as the body adjusts
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Most common AEs: nausea, diarrhea, vomiting, constipation mostly mild-to-moderate Onset: events concentrated during the 20-week titration period Discontinuation due to AEs: 4.3% (5 mg), 7.1% (10 mg), 6.2% (15 mg) vs 2.6% placebo Serious AEs: similar incidence across tirzepatide and placebo groups New signals: none identified beyond the known GLP-1 / GIP class profile Clinical significance Why SURMOUNT-1 reset the field Three observations stood out when SURMOUNT-1 was published in NEJM in 2022, and they still shape how Dr
Stalled results on a GLP-1 medication may point to an untreated hormone gap, not medication failure