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Gunderstoftes study demonstrated that genetic activation of Nrf2 increased the infectiability and the replication of HSV-2 in Keap1 (/) mouse embryonic fibroblasts (Gunderstofte et al., 2019)

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The second mechanism of action occurs downstream, in the liver

The methods involved careful preparation of biological samples, polarographic measurements of oxygen consumption, and a model of experimental hypoxia [2]

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