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Dosage can be gradually increased as tolerated to achieve the desired effects

Early detection and appropriate treatment of vitamin B12 deficiency are essential to prevent or alleviate symptoms and reduce the risk of complications

If vitamin B12 is ingested in its free (or nonprotein bound form), it will bind to a carrier protein known as R-binders or transcobalamin I that is secreted by both the salivary glands in the oropharynx and the gastric mucosal cells within the stomach.1,2,8 The free vitamin B12 ingested by mouth will remain in the bound form with an R-binder until it reaches the second segment of the duodenum in the small intestine

[9] It is on the World Health Organization's List of Essential Medicines

These approaches are not a replacement for established therapies but are considered as an additional layer of support, depending on the childs individual medical situation

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