Lillys Retatrutide: Toward the End of Incremental Metabolic Medicine Why GLP-1++ therapies are redefining what is worth developing and what is not In early December 2025, Eli Lilly announced landmark Phase 3 results for retatrutide its investigational once-weekly triple hormone receptor agonist targeting GLP-1, GIP, and glucagon
It can soothe the stomach lining and improve gut motility, reducing the incidence and severity of gastrointestinal distress
Gross spending on Medicaid prescriptions for GLP-1s for diabetes as well as for weight loss has increased from around $1 billion in 2019 to almost $9 billion in 2024 as demand for these drugs has risen, according to KFF
This test may provide context for provider conversations about whether semaglutide, tirzepatide, or dual-compound protocols align with your genetic profilethough genetic data does not guarantee medication response
Leah Joseph, MD, FACP , provides expert guidance to help you choose the best treatment for your needs
Overall though, its more about getting protein throughout the dayand less about exactly which foods provide it