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Leptin resistance is involved in the development of metabolic diseases [11]

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With respect to desensitization, all those data support the idea that agonists are able to promote a different regulation of OR as demonstrated for other GPCR such as the histamine H2 receptors (Alonso et al., 2014)

567,568 For example, tannic acid could bind to the GPX4 activation site, enhancing its activity and cellular level, which in turn regulated amyloid and tau protein deposition by reducing oxidative stress and inhibiting ferroptosis, 569 providing a promising therapeutic avenue for combating the interaction between ferroptosis and AD