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Biochemical pharmacology , 79 (7), 1000-1006

J.WardenM

Several metabolic adaptations make it challenging to sustain weight loss long-term, including hormonal changes, increased food noise, and the energy gap. Shifts in Hunger Hormones Hunger and satiety are partially driven by hormones released from the gut to the hypothalamus (a region of the forebrain)

Increased appetite can lead to binge eating and weight gain

[DOI] [PubMed] [Google Scholar] 48.Brubaker PL, Drucker DJ

McCall dives into the flaws in conventional guidelines that delay treatment until symptoms worsen or labs change, ignoring the lived experience of countless individuals