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[9] Furthermore, in the phase 3 randomized, placebo-controlled 3-year SURMOUNT-1 trial for people with obesity and prediabetes, tirzepatide compared with placebo resulted in substantial and sustained weight reduction (1523% vs 2%), significant reduction in HbA1c (0.500.65% vs 0.14%), as well as a 94% reduction in risk of progression to T2D [10]

The small size of this peptide enables it to enter cells and cell nuclei where it has been shown to induce and stabilize DNA telomere lengthening and thereby prolong the duration of cell survival in vitro

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It can cause respiratory failure (stopped breathing)

For both Gianaroli et al

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