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Nadia Ahmad, Eli Lillys medical director of obesity clinical development, said of the drugs

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In the context of constitutive HIF-2 stabilization 75 or a defective mitochondrial electron transport chain 76 , glutamine-derived -KG is reductively carboxylated through the consumption of NADPH by IDH2 to generate citrate

A minimum of 1.0 10 4 cells were analyzed per condition