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Franz CE, York TP, Eaves LJ, Mendoza SP, Hauger RL, Hellhammer DH, Jacobson KC, Levine S, Lupien SJ, Lyons MJ, Prom-Wormley E, Xian H, Kremen WS

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This research represents a significant breakthrough in understanding why some individuals experience more weight loss than others on GLP-1 medications, and why some people experience nausea while others don't

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Mechanistically, the MGBA operates through a network of interconnected signaling systems

21 Liraglutide showed no effect on the hierarchical primary endpoint of time to death, time to rehospitalisation for HF and time-averaged change in N-terminal pro B-type natriuretic peptide (NT-proBNP) from baseline to 180 days (p=0.31), with even an increased risk of emergency department visit, HF hospitalisation or all-cause death events (HR 1.36