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Alpha-synuclein Alpha-synuclein (-synuclein) is a 140 amino acid-long presynaptic protein, which is the major component of the Lewy bodies (the neuropatologic hallmark of PD), and has been implicated in the pathogenesis of PD and in synucleinopathies such as MSA and DLBD

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Studies using simulated gastric fluid have shown structural integrity preserved at pH levels as low as 1.5, attributed to its proline-rich sequence resistant to pepsin cleavage

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