Search Weight loss remains a complex challenge for many people, often involving more than just diet and exercise
Why it matters: In Eli Lillys Phase 2 trial, the highest dose produced 24.2% mean weight loss at 48 weeks the largest reduction ever reported for an anti-obesity drug at this stage
PLOS Biol
Studies also suggest that semaglutide, lixisenatide, and liraglutide may be more beneficial compared with exenatide, especially in restoring dopamine synthesis and preventing dopaminergic degeneration
Ahren B, Leguizamo Dimas A, Miossec P, Saubadu S, Aronson R
Payers should provide claims analyses of the cost of long-term care associated with obesity and related comorbidities relative to the current price tag of GLP-1s for the employers covered population to validate the preemptive savings an employer would achieve by opting to cover GLP-1s