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Recent data confirms the view that such species can propagate and spread within neural circuits, disrupting the work of brain cells (neurons) and triggering a series of toxic events (Chen and Mobley, 2019)

In natural killer T-cell lymphoma (NKTCL), blocking SLC1A1-mediated glutamine addiction in tumor cells induced PD-L1 expression and inhibited CD8(+) T-cell activity 149

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AD-specific lactylation dysregulation centers on the glycolysis-H4K12la-PKM2 positive feedback loop in hippocampal microglia and tau lactylation in vulnerable neuronsthis dual-cell lactylation network directly promotes A phagocytosis impairment and tau pathological aggregation (Zhao and Xu, 2022), a mechanism not observed in ischemia-induced acute injury or PDs dopaminergic neuron-specific degeneration

To generate MS4A15 -overexpressing Calu-1 cells, a human pLVTHM hMS4A15-FLAG-T2A-neo expression construct was cloned and lentivirus applied to parental Calu-1 cells and selected with G418 for 7 days before cell death experiments

doi: 10.1186/s12933-025-02756-y 154