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Mechanisms include: Restoration of endothelial nitric oxide synthase (eNOS) Upregulation of VEGF and FGF-2 (fibroblast growth factor 2) Reduction of oxidative stress and cytokine-induced apoptosis BPC-157 preserved endothelium-dependent vasodilation via upregulation of eNOS and suppression of vascular inflammation. Gwyer Findlay et al., Peptides 4

They generally cannot compound drugs that are "essentially copies" of commercially available products unless the drug is on the FDA shortage list

However, scientific research shows that very high-dose oral B12 (1,000-2,000 mcg) can be effective for some, as about 1% can be absorbed without intrinsic factor

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Cysteine/cystine couple is a newly recognized node in the circuitry for biologic redox signaling and control