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10.3389/fmolb.2022.1080140 [DOI] [PMC free article] [PubMed] [Google Scholar] Milhelm Z., Zanoaga O., Pop L., Iovita A., Chiroi P., Harangus A., et al

They attach to receptors on cells found in the pancreas and stomach, stimulating insulin secretion to bring down blood sugar and delaying stomach emptying

Although data from early phase trials suggest that retatrutide is well tolerated with a similar adverse event profile to GLP-1 RAs, additional research assessing long-term safety and efficacy of retatrutide in people living with obesity and/or T2D (including cardiovascular outcomes) is awaited over the next five years

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Pharmacokinetic analysis revealed it to be orally active with significantly increased metabolic stability, exhibiting a plasma half-life of 335.5 minutes, allowing for prolonged systemic availability [2]