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Funding This work was supported by the National Natural Science Foundation of China (grant number: 82000086), the Shanghai Sailing Program (grant number: 20YF1440300) for WG, the National Natural Science Foundation of China (grant number: 81870064, 82070086) for QL, and the Shanghai Jiao Tong University Medical & Engineering Cross Fund (grant number: YG2019QNA65) for HH