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The LogP values for the top hit phytochemicals depicted a good range of values (Table 2) as compared to the commercial antioxidants, such as, Vitamin E (LogP = 6.14), Masoprocol (LogP = 2.74)
In addition, local hypoxic, acidic, and low-glucose environments further augment energy metabolism reprogramming in tumor cells, which not only upregulates antiapoptotic proteins, including protein kinase B (Akt) and hexokinase 2 (HK2) but also inhibits the proliferation of T lymphocytes, facilitating tumor cell immune escape [198]
Protection against aminoglycoside-induced ototoxicity by regulated AAV vector-mediated GDNF gene transfer into the cochlea
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109, 10471057.10.1104/pp.109.3.1047 7 FraserJ
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