These findings align with existing literature that suggests multivalent inhibitors generally show increased potency due to enhanced interactions with target proteins, providing a strategic approach to the design of GSTP1 inhibitors [2426]
Tirzepatide has the stronger clinical evidence with FDA approval, the SURPASS and SURMOUNT trial programs, and the highest published weight loss data (20.9%) of any approved obesity therapeutic
Am J Med Genet 49:8387
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negative symptoms, including apathy, anhedonia, and social withdrawal
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