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This review focuses on the emerging evidence showing the involvement of ApoE in the regulation of obesity and its associated metabolic diseases

TRIUMPH-4: Efficacy at 68 weeks TRIUMPH-4 (ClinicalTrials.gov identifier NCT05931367) enrolled 445 adults with obesity or overweight plus symptomatic knee osteoarthritis and no type 2 diabetes

It helps convert food into energy, supports nerve health, aids in DNA production, and contributes to healthy brain function

Practical takeaway: FOXO4-DRI's senolytic mechanism is well-established in cell culture and animal models

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Worse still, their accumulation in tissues contributes to chronic inflammation, degenerative diseases and general ageing of the body