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Sirtuins, particularly SIRT1 [60], SIRT2 [61], and SIRT3 [62], decline with age

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The decline also impacts the bodys ability to regulate inflammation and maintain balanced cellular activity

European Pharmacopoeia PPAR peroxisome proliferator-activated receptor gamma ROS reactive oxygen species THC tetrahydrocannabinol TNF- tumor necrosis factor- Ttr transthyretin TuJ-1 neuron-specific class III beta-tubulin VCAM-1 vascular cell adhesion molecule-1 References 1 AbuhasiraR.NovackV