Vascular problems (blood flow issues) : This is one of the most common causes
Some individuals benefit from an even higher dose
Starting doses of 2.5mg for Mounjaro or 0.25mg for Wegovy are designed to prime the system
if the backwash flow rate is incorrect, the resin bed may either fail to expand sufficiently to allow for separation, orif the flow rate is too highthe resins may be fractured or flushed out of the vessel entirely
Other Side Effects Muscle pain (due to fasciculations) Increased intragastric pressure aspiration risk Increased intraocular pressure (contraindicated in glaucoma) Pharmacokinetics Routes: IV or IM Rapid metabolism by plasma pseudocholinesterase Not metabolized by acetylcholinesterase Key Parameters: Onset: 3060 seconds Duration: 610 minutes Half-life: 35 minutes Notes: Phase II block recovery may last 30 minutes or longer Duration depends on: Rate of receptor dissociation Plasma enzyme activity Drug Interactions Increase Duration of Action: Cholinesterase inhibitors (e.g., neostigmine , pyridostigmine ) Administration of neostigmine & pyridostigmine to patients to reverse non-depolarizing skeletal muscle blockade has been shown to cause profound reductions of plasma pseudocholinesterase activity for several hours duration (Mirakhur et al, 1982), an effect that can mechanistically account for the observed prolongation of succinylcholine effect by these cholinesterase inhibitors (Sunew & Hicks, 1978
This is one of the most comm
