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Heparanase is essential for the development of diabetic nephropathy in mice
More energy, a healthy immune system, great mood, and anti-aging
The 28-day (4-week) stability window is the limiting factor
In this model, ligation acts as (i) a mechanical trauma on the dentogingival area, thereby reducing tissue integrity and allowing for intense host-plaque interaction and (ii) a plaque-formation-promoting factor, thus increasing the number of bacteria
It serves a specific physiological purpose in this combination, and understanding that purpose helps you make better decisions about your protocol
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